The Correlation between Alpha-fetoprotein and Liver Function Tests

Alpha-fetoprotein in primary liver cancer and other diseases.

MONOCLONAL ANTIBODIES TO HUMAN ALPHA-FETOPROTEIN

Alpha-fetoprotein (AFP), a serum glycoprotein belonging to the onco-developmental proteins group, serves as a marker both in cancer research and in studies concerning fetal development and fetal pathophysiology. Monoclonal anti-AFP antibodies are essential reagents in developing appropriate techniques for measurement of this protein. In this study, in order to produce anti-AFP monoclonal a...

Alpha-fetoprotein impairs APC function and induces their apoptosis.

alpha-Fetoprotein (AFP) is a tumor-associated Ag, and its serum level is elevated in patients with hepatocellular carcinoma (HCC). In vitro, AFP induces functional impairment of dendritic cells (DCs). This was demonstrated by the down-regulation of CD40 and CD86 molecules and the impairment of allostimulatory function. Also, AFP was found to induce significant apoptosis of DCs, and AFP-treated ...

alpha-Fetoprotein gene sequences mediating Afr2 regulation during liver regeneration.

alpha-fetoprotein (AFP) gene expression occurs in the yolk sac, in the fetal liver and gut, and in the adult liver during regeneration and tumorigenesis. Two unlinked genes determine the level of AFP gene expression in adult mice: Afr1 regulates the basal level of expression in the normal adult liver, and Afr2 regulates the increase in expression during liver regeneration. It has been shown tha...

Serum alpha-fetoprotein in patients with nonalcoholic fatty liver disease.

We read with interest the Kara et al1, article showing similar serum alpha-fetoprotein (AFP) levels among men with nonalcoholic simple steatosis (SS), steatohepatitis and controls of lower body mass index (BMI), and no discriminating value for NASH1. Following this publication, we performed a post-hoc analysis in a Greek cohort (30 [22 women] patients with biopsy-proven nonalcoholic fatty liver...